Telomeres together
نویسندگان
چکیده
منابع مشابه
Telomeres together
sing the immune system to attack cancers is a good idea, but it may only work if Toll-like receptors (TLRs) are activated to break tolerance, say Yiping Yang (Duke University, Durham, NC), Drew Pardoll (Johns Hopkins, Baltimore, MD), and colleagues. The favored method for delivering cancer immunotherapy has been dendritic cells: they are the central antigen-presenting cells for generating T cel...
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Mutant phagosomes bite off more than they can chew A kbar et al. reveal that the fl y homologue of a gene mutated in human disease encodes a protein required for phagosome matura-tion and digestion of pathogens. The HOPS complex is a multi-subunit tethering factor that regulates vacuole fusion in budding yeast. Metazoans express two versions of the HOPS subunits Vps16p and Vps33p. Vps16A and Vp...
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Nuclear receptors bind chromosome ends in "alternative lengthening of telomeres" (ALT) cancer cells that maintain their ends by homologous recombination instead of telomerase. Marzec et al. now demonstrate that, in ALT cells, nuclear receptors not only trigger distal chromatin associations to mediate telomere-telomere recombination events, but also drive chromosome-internal targeted telomere in...
متن کاملThe Apollo 5′ Exonuclease Functions Together with TRF2 to Protect Telomeres from DNA Repair
A major issue in telomere research is to understand how the integrity of chromosome ends is preserved . The human telomeric protein TRF2 coordinates several pathways that prevent checkpoint activation and chromosome fusions. In this work, we identified hSNM1B, here named Apollo, as a novel TRF2-interacting factor. Interestingly, the N-terminal domain of Apollo is closely related to that of Arte...
متن کاملTelomeres
What are they? Telomeres are the natural tips of chromosomes. They consist of tandem arrays of simple G-rich repetitive DNA sequences that are complexed with proteins. The fundamental tools for keeping telomeres healthy are amazingly similar in both single cell eukaryotes, such as yeast and ciliated protozoa, and human cells. What do they do? Telomeres have two important duties. First, they are...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2004
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1652rr3